Conformational calculations for the oligopeptides. A cyclic dodecapeptide
نویسندگان
چکیده
منابع مشابه
The role of hydroxyproline in collagen folding: conformational energy calculations on oligopeptides containing proline and hydroxyproline.
We have observed that the rate of folding of the enzymatically hydroxylated form of poly(G1yPro-Pro) into the triple-helical conformation is considerably higher than that of the unhydroxylated polypeptide [R. K. Chopra and V. S. Ananthanarayanan (1982) Proc. Nutl. Acud. Sci. USA 79, 7180-71841. In this study, we examine a plausible kinetic pathway for triple-helix formation by selecting peptide...
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We examined the 220-MHz NMR spectra for a series of oligopeptides derived from gamma-ethyl L-glutamate, an octapeptide based on beta-methyl L-aspartate, and a low molecular weight L-glutamate polymer ([unk]DP = 20) in deuterochloroform-trichloroacetic acid. A definite transition from folded to nonhelical forms was established for the glutamate systems. The aspartate behavior is explained by a p...
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A detailed understanding of themechanistic principles which govern peptide and protein selfassembly is of considerable biomedical and biotechnological importance. Owing to the diversity of peptide and protein sequences which have been shown to aggregate into ordered structures, the ability to self-assemble is now recognized as an inherent feature of the polypeptide backbone. It is therefore of ...
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15 صفحه اولNew optimization method for conformational energy calculations on polypeptides: Conformational space annealing
A new optimization method is presented to search for the global minimum-energy conformations of polypeptides. The method combines essential aspects of the build-up procedure and the genetic algorithm, and it introduces the important concept of ‘‘conformational space annealing.’’ Instead of considering a single conformation, attention is focused on a population of conformations while new conform...
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ژورنال
عنوان ژورنال: Biopolymers
سال: 1978
ISSN: 0006-3525,1097-0282
DOI: 10.1002/bip.1978.360170617